http://scholars.nricm.edu.tw/handle/123456789/44
Title: | Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3 | Authors: | Cheng, Ching-Feng Ku, Hui-Chen Cheng, Jing-Jy Chao, Shi-Wei Li, Hsiao-Fen Lai, Pei-Fang Chang, Che-Chang Don, Ming-Jaw Chen, Hsi-Hsien Lin, Heng |
Issue Date: | 2019 | Journal: | Communications Biology | Abstract: | Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3?/?) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein�Vstearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders. | Description: | Communications Biology 2: 389 | URI: | http://localhost/handle/123456789/44 | DOI: | 10.1038/s42003-019-0624-y |
Appears in Collections: | 張芳榮 |
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