|Title:||Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3||Authors:||Cheng, Ching-Feng
|Issue Date:||2019||Journal:||Communications Biology||Abstract:||Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3?/?) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein�Vstearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders.||Description:||Communications Biology 2: 389||URI:||http://localhost/handle/123456789/44||DOI:||10.1038/s42003-019-0624-y|
|Appears in Collections:||張芳榮|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.