http://scholars.nricm.edu.tw/handle/123456789/44
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheng, Ching-Feng | en_US |
dc.contributor.author | Ku, Hui-Chen | en_US |
dc.contributor.author | Cheng, Jing-Jy | en_US |
dc.contributor.author | Chao, Shi-Wei | en_US |
dc.contributor.author | Li, Hsiao-Fen | en_US |
dc.contributor.author | Lai, Pei-Fang | en_US |
dc.contributor.author | Chang, Che-Chang | en_US |
dc.contributor.author | Don, Ming-Jaw | en_US |
dc.contributor.author | Chen, Hsi-Hsien | en_US |
dc.contributor.author | Lin, Heng | en_US |
dc.date.accessioned | 2020-01-15T03:55:26Z | - |
dc.date.available | 2020-01-15T03:55:26Z | - |
dc.date.issued | 2019/10/24 | - |
dc.identifier.uri | http://localhost/handle/123456789/44 | - |
dc.description | Communications Biology 2: 389 | en_US |
dc.description.abstract | Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3?/?) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein�Vstearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders. | en_US |
dc.relation.ispartof | Communications Biology | en_US |
dc.title | Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3 | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1038/s42003-019-0624-y | - |
dc.identifier.pmid | 31667363 | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Division of Basic Chinese Medicine | - |
crisitem.author.dept | Division of Chinese Medicinal Chemistry | - |
crisitem.author.parentorg | National Research Institute of Chinese Medicine | - |
crisitem.author.parentorg | National Research Institute of Chinese Medicine | - |
Appears in Collections: | 張芳榮 |
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