|Title:||Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis||Authors:||Huang, Hung-Tse
|Keywords:||Momordica cochinchinensis;oleanane-type triterpene glycoside;mocochinoside;anti-inflammatory;anti-proliferation||Issue Date:||2019||Journal:||Natural Product Research||Abstract:||This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-�]-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2?D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC50 5.41???11.28?�gM. Compounds 3, 4, and 7 (IC50 8.42???19.74?�gM) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines.||Description:||Natural Product Research 1-8||URI:||http://localhost/handle/123456789/46||DOI:||10.1080/14786419.2019.1666383|
|Appears in Collections:||張芳榮|
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