http://scholars.nricm.edu.tw/handle/123456789/46
Title: | Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis | Authors: | Huang, Hung-Tse Lin, Yu-Chi Zhang, Li-Jie Liaw, Chia-Ching Chen, Hsin-Yen Hsueh, Ming-Tung Kuo, Yao-Haur |
Keywords: | Momordica cochinchinensis;oleanane-type triterpene glycoside;mocochinoside;anti-inflammatory;anti-proliferation | Issue Date: | 2019 | Journal: | Natural Product Research | Abstract: | This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-�]-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2?D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC50 5.41???11.28?�gM. Compounds 3, 4, and 7 (IC50 8.42???19.74?�gM) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines. | Description: | Natural Product Research 1-8 | URI: | http://localhost/handle/123456789/46 | DOI: | 10.1080/14786419.2019.1666383 |
Appears in Collections: | 張芳榮 |
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