http://scholars.nricm.edu.tw/handle/123456789/45
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huang, Cheng | en_US |
dc.contributor.author | Huang, Yu-Ling | en_US |
dc.contributor.author | Wang, Chia-Chi | en_US |
dc.contributor.author | Pan, Yi-Ling | en_US |
dc.contributor.author | Lai, Yu-Heng | en_US |
dc.contributor.author | Huang, Hsiu-Chen | en_US |
dc.date.accessioned | 2020-01-15T03:55:27Z | - |
dc.date.available | 2020-01-15T03:55:27Z | - |
dc.date.issued | 2019/3/13 | - |
dc.identifier.uri | http://localhost/handle/123456789/45 | - |
dc.description | Journal Of Agricultural And Food Chemistry 67(10): 2818-2830 | en_US |
dc.description.abstract | Ampelopsins A and C are resveratrol oligostilbenes whose role in cancer development remains unknown. This study evaluated the antimetastatic and apoptosis-inducing properties of ampelopsins A and C in MDA-MB-231 cells. The IC50 values of ampelopsins A and C against MDA-MB-231 cells at 72 h were 38.75 �� 4.61 and 2.71 �� 0.21 �gM, respectively. However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. Additionally, antiproliferation effects of ampelopsin C were enhanced when combined with luteolin and chrysin compared to either two or a single agent in MDA-MB-231 cells. Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer. | en_US |
dc.relation.ispartof | Journal Of Agricultural And Food Chemistry | en_US |
dc.subject | ampelopsin A | en_US |
dc.subject | ampelopsin C | en_US |
dc.subject | MDA-MB-231 | en_US |
dc.subject | AxL | en_US |
dc.subject | FYN | en_US |
dc.title | Ampelopsin A and ampelopsin C induce apoptosis and metastasis through down-regulating AxL, TYRO3, and FYN expressions in MDA-MB-231 breast cancer cells | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1021/acs.jafc.8b06444 | - |
dc.identifier.pmid | 30789269 | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Division of Chinese Medicinal Chemistry | - |
crisitem.author.parentorg | National Research Institute of Chinese Medicine | - |
Appears in Collections: | 黃鈺玲 |
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