|Title:||Ampelopsin A and ampelopsin C induce apoptosis and metastasis through down-regulating AxL, TYRO3, and FYN expressions in MDA-MB-231 breast cancer cells||Authors:||Huang, Cheng
|Keywords:||ampelopsin A;ampelopsin C;MDA-MB-231;AxL;FYN||Issue Date:||2019||Journal:||Journal Of Agricultural And Food Chemistry||Abstract:||Ampelopsins A and C are resveratrol oligostilbenes whose role in cancer development remains unknown. This study evaluated the antimetastatic and apoptosis-inducing properties of ampelopsins A and C in MDA-MB-231 cells. The IC50 values of ampelopsins A and C against MDA-MB-231 cells at 72 h were 38.75 �� 4.61 and 2.71 �� 0.21 �gM, respectively. However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. Additionally, antiproliferation effects of ampelopsin C were enhanced when combined with luteolin and chrysin compared to either two or a single agent in MDA-MB-231 cells. Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer.||Description:||Journal Of Agricultural And Food Chemistry 67(10): 2818-2830||URI:||http://localhost/handle/123456789/45||DOI:||10.1021/acs.jafc.8b06444|
|Appears in Collections:||黃鈺玲|
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