http://scholars.nricm.edu.tw/handle/123456789/40
Title: | 2-Iodo-4'-methoxychalcone attenuates methylglyoxal-induced neurotoxicity by activation of GLP-1 receptor and enhancement of neurotrophic signal, antioxidant defense and glyoxalase pathway | Authors: | Fang-Rong Chang Yu-Ting Tseng Yi-Hong Tsai Ferenc Fülöp Yi-Ching Lo |
Keywords: | halogen-containing chalcones;methylglyoxal;antioxidant defense;glyoxalase pathway;neuroprotection;neurotrophic effect | Issue Date: | 16-Jun-2019 | Journal: | Molecules | Abstract: | Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging. 2-iodo-4′-methoxychalcone (CHA79), a synthetic halogen-containing chalcone derivative, has been reported its anti-diabetic activity. This study aims to investigate the potential protective capability of CHA79 against MG-mediated neurotoxicity in SH-SY5Y cells. Results indicated CHA79 increased viability of cells and attenuated the rate of apoptosis in MG-exposed SH-SY5Y. CHA79 up-regulated expression of anti-apoptotic protein (Bcl-2) and down-regulated apoptotic proteins (Bax, cytochrome c, caspase-3, caspase-9). Moreover, CHA79 significantly up-regulated expression of neurotrophic factors, including glucagon-like peptide-1 receptor (GLP-1R), brain derived neurotrophic factor (BDNF), p75NTR, p-TrkB, p-Akt, p-GK-3β and p-CREB. CHA79 attenuated MG-induced ROS production and enhanced the antioxidant defense including nuclear factor erythroid 2-related factor 2 (Nrf2), HO-1, SOD and GSH. Furthermore, CHA79 attenuated MG-induced reduction of glyoxalase-1 (GLO-1), a vital enzyme on removing AGE precursors. In conclusion, CHA79 is the first novel synthetic chalcone possessing the GLP-1R and GLO-1 activating properties. CHA 79 also exhibits neuroprotective effects against MG toxicity by enhancing neurotrophic signal, antioxidant defense and anti-apoptosis pathway. | Description: | Molecules 24(12): pii: E2249 | URI: | http://localhost/handle/123456789/40 | DOI: | 10.3390/molecules24122249 |
Appears in Collections: | 張芳榮 |
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2019-ChangFR-2-Iodo-4′-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity.pdf | 全文檔 | 2.25 MB | Adobe PDF | View/Open |
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